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NEUROLOGY 1975;25:570
© 1975 American Academy of Neurology

Mononeuropathy multiplex as a complication of amphetamine angiitis

CALVIN R. STAFFORD, M.D., BRUCE M. BOGDANOFF, M.D., LAWRENCE GREEN, M.D. and HARVEY B. SPECTOR, M.D.

Departments of Neurology, Neurophysiology, and Pathology, Crozer-Chester Medical Center, Chester, PA, and the Division of Neurology (Department of Medicine), Hahnemann Medical College and Hospital, Philadelphia.

A patient who abused multiple drugs developed a rapidly progressive mononeuropathy multiplex, which appeared to respond to corticosteroid therapy with partial resolution. Intravenous methamphetamine had been used almost exclusively from the fourth month prior to the onset of symptoms. Biopsy material revealed a necrotizing angiitis involving medium and small sized arteries, capillaries, and venules, typical of a hypersensitivity-type angiopathy, rather than the previously reported polyarteritis nodosa-type lesions secondary to illicit drugs. The apparent response to corticosteroids suggests that these agents might be useful in the treatment of some complications of drug abuse.

Received for publication October 28, 1974.

Requests for reprints should be addressed to Dr. Bogdanoff at Department of Neurology, Crozer-Chester Medical Center, 15th Street and Upland Avenue, Upland, Chester, PA 19013.




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