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Cerebrospinal fluid proteins in multiple sclerosis

Immunodiagnostic Laboratory, Institute of Microbiology and Hygiene of Montreal (Dr. Lamoureux and Mr. Jolicoeur), the Service of Neurology, Notre-Dame Hospital (Drs. Giard and St-Hilaire), and the Service of Neurology, Maisonneuve Hospital (Dr. Duplantis), Montreal, Canada.

Various CSF proteins were studied in 255 definite multiple sclerosis patients at various disease stages and compared with corresponding values obtained from 174 controls. The CSF changes in acute multiple sclerosis patients included a significant increase of total proteins and of gamma globulin, IgG, IgA, IgM, alpha-2 ceruloplasmin, 7S-gamma-1, and cytotoxic index for nerve cells in tissue culture, and significant decreases of pre-albumin, alpha-1, and alpha-2 and of the beta/gamma globulin ratio. The CSF levels of IgG, IgA, and IgM remained significantly higher in steroid-treated multiple sclerosis patients than in controls, but the levels often were significantly reduced while patients were on treatment or in remission. During remission or treatment with ACTH and/or steroids, the alpha-2 ceruloplasmin, 7S-gamma-1, and cytotoxic index were significantly reduced and the pre-albumin, alpha-1, and alpha-2 globulin classes and the beta/gamma ratio showed a tendency to return to normal.

This work was supported by a grant from the Multiple Sclerosis Society of Canada.

Received for publication September 30, 1974.

Dr. Lamoureux' address is Immunodiagnostic Laboratory, Institute of Microbiology and Hygiene of Montreal, P.O. Box 100, Laval des Rapides, Quebec, Canada.