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Isoniazid as an inhibitor of primidone metabolism

EEG Laboratory, University of Maryland Hospitals, University of Maryland, Baltimore (Dr. Sutton), and Section on Epilepsy, Applied Neurologic Research Branch, Collaborative and Field Research, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland (Dr. Kupferberg).

Isoniazid inhibited the metabolism of primidone in a patient with focal seizures. The steady-state serum level of primidone rose when the patient received both drugs simultaneously. The serum levels of the primidone metabolites, phenobarbital and phenylethyl-malonamide, fell and the rats of metabolism of primidone decreased. The results are similar to those observed when isoniazid is administered with diphenylhydantoin.

Received for publication May 27, 1975.

Dr. Kupferberg's address is Building 36, Room 5D-19, NINCDS, NIH, Bethesda, MD 20014.

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