HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by BIRD, T. D. Articles by OMENN, G. S. Search for Related Content PubMed PubMed Citation Articles by BIRD, T. D. Articles by OMENN, G. S.

Monozygotic twins with Huntington's disease in a family expressing the rigid variant

Department of Medicine, Divisions of Medical Genetics and Neurology, University of Washington School of Medicine, Seattle.

A set of male monozygotic twins concordant for Huntington's disease is described. The monozygosity of the twins and the diagnosis of Huntington's disease are well established. The twins are now age 30, and although the severity of their chorea differs, they have a similar degree of mental deficit. This family is of additional interest because the daughter of one of the twins has childhood Huntington's disease, and the mother of the twins had the adult-onset rigid variant of the disease. Such unusual families afford some insight into the variability of the clinical manifestations of this hereditary disease.

Supported by NIH grants 1 F22 NS01561–01, GM15253 and Research Career Development Award GM43122 (G.S.O.).

Received for publication October 9, 1974.

Dr. Bird's address is Division of Neurology and Medical Genetics, University of Washington, Seattle, WA 98195.

This article has been cited by other articles:

				J. H. Friedman, M. E. Trieschmann, R. H. Myers, and H. H. Fernandez Monozygotic Twins Discordant for Huntington Disease After 7 Years Arch Neurol, June 1, 2005; 62(6): 995 - 997. [Abstract] [Full Text] [PDF]

				L. A. Farrer and P. M. Conneally Predictability of Phenotype in Huntington's Disease Arch Neurol, January 1, 1987; 44(1): 109 - 113. [Abstract] [PDF]