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From the Laboratory of Neurochemistry and Department of Experimental Medicine, University of Louvain, Belgium
SUMMARYCSF protein electrophoresis in agar gel was performed in 2,043 patients. Among them, 323 patients were classified as having MS. The essential feature of the gamma globulins in CSF from MS patients and other inflammatory CNS diseases resided in their restricted heterogeneity distribution. This peculiar electrophoretic pattern occurs in 75.2 to 86.9% of MS patients, depending upon the diagnostic category (possible, probable, or definite). The differences were significant. In MS patients there was also a positive correlation between the degree of disability and the frequency of gamma pattern when Grade I and Grade III were compared, but no correlation was found between the duration and course of the disease on the one hand and the CSF gamma globulin changes on the other hand.
In the other patients, this frequency varied between 2. to 5.1%, except for the group with inflammatory CNS diseases in which it reached 39.6%. The diagnostic value of the method employed is discussed and emphasized.
Dr. Laterre's address is Department of Neurology-Neurosurgery, University Hospital St. Raphael, Voer des Capucins, 35, Kapucijnenvoer, Louvain, Belgium.
This work was supported in part by the Fonds de la Recherche Scientifique Medicale.
Submitted for publication Oct. 5, 1969; resubmitted Jan. 28, 1970; accepted Feb. 16, 1970.
The expert assistance of Miss H. Heulle is gratefully acknowledged.
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